2/27/2024 0 Comments Integrity Plus free![]() Was the organization included in consolidated, independent audited financial statements for the tax year? Is the organization a section 501(c)(4), 501(c)(5), or 501(c)(6) organization that receives membership dues, assessments, or similar amounts as defined in Revenue Procedure 98-19?ĭid the organization maintain any donor advised funds or any similar funds or accounts for which donors have the right to provide advice on the distribution or investment of amounts in such funds or accounts?ĭid the organization receive or hold a conservation easement, including easements to preserve open space, the environment, historic land areas, or historic structures?ĭid the organization maintain collections of works of art, historical treasures, or other similar assets?ĭid the organization report an amount for escrow or custodial account liability serve as a custodian or provide credit counseling, debt management, credit repair, or debt negotiation services?ĭid the organization, directly or through a related organization, hold assets in temporarily restricted endowments, permanent endowments, or quasi-endowments?ĭid the organization report an amount for land, buildings, and equipment?ĭid the organization report an amount for investments-other securities that is 5% or more of its total assets?ĭid the organization report an amount for investments-program related that is 5% or more of its total assets?ĭid the organization report an amount for other assets that is 5% or more of its total assets?ĭid the organization report an amount for other liabilities?ĭid the organization's separate or consolidated financial statements for the tax year include a footnote that addresses the organization's liability for uncertain tax positions under FIN 48 (ASC 740)?ĭid the organization obtain separate, independent audited financial statements for the tax year? Is the organization required to complete Schedule B, Schedule of Contributors?ĭid the organization engage in direct or indirect political campaign activities on behalf of or in opposition to candidates for public office?ĭid the organization engage in lobbying activities, or have a section 501(h) election in effect during the tax year? Using cfDI and CTCs as a combined diagnostic tool for no-MBC could improve diagnostic sensitivity and specificity but more samples will be needed.Ĭell-free DNA cell-free DNA integrity circulating tumor cell no distant metastasis breast cancer.Is the organization described in section 501(c)(3) or 4947(a)(1) (other than a private foundation)? Our results suggest that cfDI is a potential diagnostic biomarker of no-MBC. Combined with CTCs, cfDI reduced the false positive rate from 50% to 10.71% and increased the area under the curve value from 0.66 to 0.68. Receiver operating characteristic curve analysis also suggested that cfDI was superior to CTCs or CA153. Spearman's rho showed that the correlation coefficient between cfDI and CTCs was 0.278 (p = 0.04) in the no-MBC group. McNemar's test suggested that cfDI had stronger diagnostic power than CTCs, cfDNA concentration, or CA153 (p < 0.001). Subgroup analysis showed that decreased cfDI seem to be associated with risk factors such as age 14% (mean cfDI = 0.57), tumor size > 2 cm (mean cfDI = 0.58), and positive lymph node status (mean cfDI = 0.56), but had no statistical significance. The no-MBC group had significantly lower mean cfDI (0.58) than the BBT group (0.74, p = 0.004). ![]() We assessed the plasma cfDI of 84 patients with no-MBC and 30 patients with BBT using quantitative PCR and compared it with circulating tumor cells (CTCs) and carbohydrate antigen 153 (CA153). However, no specific study has evaluated the diagnostic ability of cfDI in patients with no distant metastasis breast cancer (no-MBC) and benign breast tumor (BBT) to date. Cell-free DNA integrity (cfDI) is a promising diagnostic and prognostic biomarker in breast cancer.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |